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发布于:2018-11-5 04:35:58  访问:42 次 回复:0 篇
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Aston, Birmingham B15 2TT, UK Full list of author information is
This is an Open Access MLN4924 MedChemExpress article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, Pimodivir provided the original work is properly cited.Bennett et al. In order to meet the healthcare needs of the diverse populations which exists in the UK [11], it is important to know if any differences exist in the reporting of symptoms of disease and also whether current diagnostic tools designed in European populations are applicable in the diagnosis of disease in other ethnic groups. The purpose of this sub-study to the Ethnic-Echocardiographic Heart of England Screening Survey (EECHOES) [14] was to determine the diagnostic accuracy of the ECQ to diagnose PAD, defined by ABPI <0.9, in languages of the Indian sub-continent and also in English speaking Black African-Caribbean groups, with a view to their use or adaptation in a follow up epidemiological survey.MethodsTranslation of Edinburgh Claudication of QuestionnaireA diagrammatic representation of the translation process for each South Asian langu.Aston, Birmingham B15 2TT, UK Full list of author information is available at the end of the article?2011 Bennett et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Bennett et al. BMC Medical Research Methodology 2011, 11:85 http://www.biomedcentral.com/1471-2288/11/Page 2 ofBackground Peripheral artery disease (PAD) is an important healthcare problem in developed nations and is associated with considerable morbidity and mortality. Intermittent claudication (IC) is the most common symptomatic manifestation of PAD, and typically occurs in up to one third of patients with this disease [1]. Intermittent claudication is characterised by pain, aching or cramping in the calf, buttock, hip or thigh on ambulation that resolves upon rest. Symptoms arise from an inadequate blood supply to the peripheral arteries of the legs that result in anaerobic metabolism and build up of lactic acid within the muscles. Only about a quarter of patients with IC will ever significantly deteriorate [1]. Ankle brachial pressure index (ABPI) is the gold standard for the assessment of both PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/27196668 PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/25636517 asymptomatic and symptomatic PAD [2]. A value of <0.9 is indicative of PAD, with sensitivity and specificity of 95 for detecting angiogram positive disease [3-5]. Intermittent claudication can be diagnosed with the use of a questionnaire along with evidence of PAD. The Edinburgh Claudication Questionnaire (ECQ) was first validated by Leng et al. 1992 after noting that the previous WHO/Rose questionnaire had low sensitivity [6] This patient administered questionnaire was administered to a predominantly European population and was found to be 91.3 sensitive and 99.3 specific for IC in comparison to a doctor made diagnosis [6]. It was also found to have excellent reliability after repeating the questionnaire at 6 months. The ECQ has been validated in French and Brazilian Portugese [7-9] and in English in a community based study in the Netherlands [10] though not amongst languages of the Indian Subcontinent or amongst Black African-Caribbean groups.
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